WAS SIND UND WAS KÖNNEN STAMMZELLEN? Was sind und was können Stammzellen


Verwendung von PRP in Behandlungen von Sehnen- und Bandverletzungen
PRP use in treating tendons and ligaments

Effects of platelet rich plasma and acellular bone marrow on gene expression patterns and DNA content of equine suspensory ligament explant cultures. Schnabel LV, Sonea HO, Jacobson MS, Fortier LA - Equine Vet J. 2008, 40(3) 260-5

Effects of platelet-rich plasma on the quality of repair of mechanically induced core lesions in equine superficial digital flexor tendons: A placebo-controlled experimental study. Bosch G, van Schie HT, de Groot MW, Cadby JA, van de Lest CH, Barneveld A, van Weeren PR. J Orthop Res

Interalesional injection of platelet-rich plasma followed by controlled exercise for treatment of midbody suspensory ligament desmitis in Standardbred racehorses Martin Waselau, W.Wesley Sutter, Ronald L. Genovese, Alicia L. Bertone - Journal of the American Veterinary Medical Association - 2008, 232, 10, 1515-1520

Nucleotide structure of equine platelet-derived growth factor-A and -B and expression in horses with induced acute tendonitis. Donnelly BP, Nixon AJ, Haupt JL, Dahlgren LA, Am J Vet Res. 2006, 67(7), 1218-25

Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons. Schnabel LV, Mohammed HO, Miller BJ, Mc Dermott WG, Jacobson MS, Santangelo KS, Fortier LA - J Orthop Res. 2007, 25(2), 230-40

Computerised analysis of standardised ultrasonographic images to monitor the repair of surgically created core lesions in equine superficial digital flexor tendons following treatment with intratendinous platelet richt plasma or placebo. Bosch G, RenÉ van Weeren P, Barneveld A, van Schie HT. Vet J. 2009 Nov 19

Verwendung von PRP in der Wundbehandlung bei Pferden
PRP use in equine wound healing

Effects of platelet-rich plasma gel on skin healing in surgical wound in horses. De Rossi R, Coelho AC, de Mello GS, Frazílio FO, Leal CIR, Facco GG, Brum KB. Acta Cir Bras. 2009 Jul-Aug; 24(4):276-81

Effects of platelet-rich plasma on the repair of wounds on the distal aspect of the forelimb in horses. Monteiro SO, Lepage OM, Theoret CL. Am J Vet Res. 2009 Feb;70(2):277-82

Topical treatments in equine wound management. Dart All, Dowling BA, Smith CL. Vet Clin North Am Equine Pract. 2005 Apr; 21(1):77-89, vi-vii. Review

Platelet-rich plasma gel promotes differentation and regeneration during equine wound healing. Carter CA, Jolly DG, Worden CE Sr, Hendren DG, Kane CJ. Exp Mol Pathol. 2003 Jun;74(3):244-55

Verwendung von PRP bei Gelenkserkrankungen des Pferds
PRP use in treating equine joint disease

Autologous platelet-richplasma injected intraarticularly diminished synovial effusion and degree of lameness in horses affected with server joint disease. J.U. Carmona, D. Arg, elles, F. Climent, M. Prades, R. Soler, F. Vidal, L. Orozco. 14th Annual Scientific Meeting of the European College of Veterinary Surgeons. Lyon France. July 7-9, 2005.

The use of platelet-rich plasma in arthroscopy and sports medicine: optimizing the healing environment. Lopez-Vidriero E, Goulding KA, Simon DA, Sanchez M, Johnson DH. Department of Orthopaedics, the Ottawa Hospital, Ottawa, Ontario, Canada.


Reference list

Adult and late fetal equine tendon contain cell populations with weak progenitor properties in comparison to bone marrow derived mesenchymal stem cells. Strassburg S, Smith RK, Goodship AE, Hardingham TE, Clegg PD - Proceedings of the 52nd Orthopaedic Research Society (2006)

Anabolic effects of acellular bone marrow, platelet rich plasma, and serum on equine ligament fibroblasts in vitro. Smith JJ, Scott CM, Ross MW, Smith RKW - Vet Surg (2003), 32.496

Autologous mesenchymal stem cell-mediated repair of tendon. HA, Butler DL, Boivin GP, Smith FN, Malaviya P, Huibregtse B, Caplan AL - Tissue Eng 5(3) (1999), 267-77

Cell growth characteristics and differentation frequency of adherent equine bone marrow derived mesenchymal stromal cells: adipogenic and osteogenic capacity. Vidal MA, Kilroy GE, Johnson JR, Lopez MJ, Moore RM, Gimble JM - Vet Surg 35(7) (2006), 601-10

Equine peripheral blood-derived progenitors in comparison to bone marrow-derived mesenchymal stem cells. Koerner J, Nesic D, Romero JD, Brehm W, Mainil-Varlet P, Grogan SP - Stem Cells 24(6) (2006), 1613-9

Establishment of tendon-derived cell lines exhibiting pluripotent mesenchymal stem cell-like property. Salingcarnboriboon R, Yoshitake H, Tsuji K, Obinata M, Amagasa T, Nijuji A, Noda M - Exptal cell res 287 (2003), 279-300

Extracellular matrix cues for mesenchymal stem cell differentiation. Richardson LE, Dudhia J, Sadler CJ, Goodship AE, Smith RKW - Proceedings of the 53rd Orthopaedic Research Society, 472 (2007)

Harnessing the stem cell for the treatment of tendon injuries: heralding a new dawn? Smith RK, Webbon PM - Br J Sports Med 39 (2005), 582-584

Medical management of superficial digital flexor tendinitis: A comparative study in 219 horses (1992-200) Dyson SJ Equine Vet J 36(2004), 415

Mesenchymal stem cell therapy in equine musculoskeletal disease: scientific fact or clinical fiction? Taylor SE, Smith RK, Clegg PD - Equine Vet J. 39(2007), 172-180

Mesenchymal stem cell treatment of suspensory ligament branch desmitis: post mortem findings in a 10 year old Russian Warmblood gelding - a case report. Mountford DR, Smith RKW, Patterson -Kane JC - Pferdeheilkunde 22(5) (2006), 559-56

Repair of superficial osteochondral defects with an autologous scaffold-free cartilage construct in a caprine model: implantation method and short-term results. Brehm W, Aklin B, Yamashita T, Rieser F, Trub T, Jakob RP, Mainli VarletP, Osteoarthritis an Cartilage 14(12) (2006), 1214-26

Stem cells in veterinary medicine - attempts at regenerating equine tendon after injury. Richardson LE, Dudhia J, Clegg PD and Smith RKW - Trends Biotechnology 25 (2007), 409-416

Stem cells: classifications, controversies and clinical applications. Fortier LA - Vet Surg 34(5) (2005), 415-23

The pathobiology and repair of tendon and ligament injury. Goodship AE, Birch HL, Wilson AM - Vet Clin North Am Equine Pract 1 (1994), 323

Tissue engineering of ligaments by human bone marrow stromal cells in a liquid fibrin matrix: histological, biomechanical and molecular biological results of a study with immunodeficient rats. Hankemeier S, van Greinsven M, Hurschler C, Westdoerp J, Jagodzinski M, Bosch U, Krettek C, Zeichen J - Proceedings of the 51st Orthopaedic Research Society Meeting, 157 (2005)